VALIUM can be a federal managed substance (C-IV) since it includes diazepam which might be abused or bring about dependence. Maintain VALIUM in a secure place to avoid misuse and abuse.
diazepam will improve the amount or outcome of flibanserin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Increased flibanserin adverse consequences might take place if coadministered with various weak CYP3A4 inhibitors.
diazepam will enhance the amount or impact of tazemetostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
地西泮在口服後，迅速被身體吸收，藥效很快開始，以靜脈注射，藥效更快。地西泮經肝臟代謝，其代謝物經腎臟排泄，只有極少量的地西泮沒有被代謝便排泄。
levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will enhance the degree or outcome of diazepam by lowering metabolism.
Notify patients and caregivers that probably fatal additive consequences may possibly happen if diazepam is used with opioids and that this kind of prescription drugs should not be used concomitantly Except supervised by a well being care service provider
Patients within the aforementioned groups are monitored incredibly intently through therapy for indications of abuse and progress of dependence. Therapy is usually recommended being discontinued if any of such indications are noted.
Risks of dependence and withdrawal maximize with more time treatment period and higher everyday dose; Whilst injection is indicated only for intermittent use, if applied more regularly than advised, abrupt discontinuation or swift dosage reduction may possibly precipitate acute
Watch Carefully (1)oxcarbazepine will lessen the extent or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Coadministration of encorafenib with delicate CYP3A4 substrates may possibly bring about increased toxicity or lessened efficacy of these agents.
Doses of diazepam are proposed to get about half of People provided to young men check here and women, and treatment method is restricted to a optimum of two weeks. Extensive-acting benzodiazepines which include diazepam are not recommended with the elderly.[20] Diazepam may also be risky in geriatric people owing to some appreciably enhanced hazard of falls.[62]
Pregnancy. It's not at all known if or how diazepam could impact pregnancy or harm an unborn child. Taking diazepam over the later stages of pregnancy can cause withdrawal and the subsequent signs and symptoms in newborns.
Alcohol in combination with diazepam may possibly trigger a synergistic improvement of the hypotensive Houses of benzodiazepines and Liquor.[ninety five]
Diazepam is a medication by using a high hazard of misuse and can result in drug dependence. Urgent action by nationwide governments has been suggested to boost prescribing patterns of benzodiazepines for example diazepam.